In this article we studied in creams are topical preparation for the applied on the skin. “viscous liquid or semisolid emulsion is called as cream" The topical formulation is used to introduced the drug into the skin or mucous membrane of skin. And also for the different skin disorders. In this article we also discussed in the types of creams and there examples. Then studied the creams is pharmaceutical product because they prepared on the basis of technology in pharmaceutical industry. They may be medicated or non medicated or they are herbal, ayurvedic & allopathic. Skin reflects origins, lifestyle, age and state of health. Skin creams are mainly classified as O/W & W/O. Then they will be emmulsified by emulsifying agent. In the skin creams various vitamins are used like vit A, E, & D3 are the synthetic and fatty acid (EFA) are used. In which also used the water, oil, fat, Waxes, colours, glycol and etc. Creams have the number of advantages like easy apply, more effective compares to other avoid risk, drugs are absorb perfectly but in which disadvantages also present like, skin irritation can occur due to adjuent, large size drug are not absorb perfectly and etc.

Targeted drug delivery is an advanced method of delivering drugs to patients in such a targeted order that increases the concentration of the delivered drug only on the body part of interest (organs/tissues/cells), which in turn improves the effectiveness of the treatment while reducing side effects of drug administration. Basically, drug targeting should help the drug molecule to preferentially reach the desired site. The inherent advantage of this technique results in the administration of the required drug with its reduced dose and reduced side effect. This inherent advantage of a targeted drug delivery system is also strongly recognized by research and development in the clinical and pharmaceutical fields as the backbone of therapeutics and diagnostics. Various drug carriers that can be used in this advanced delivery system are soluble polymers, biodegradable microsphere polymers (synthetic and natural), neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles, and immune micelles. The goal of a targeted drug delivery system is to prolong, localize, target, and have a protected drug interaction with the diseased.

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