Iridial pigmentation and eyelash change occurred at a high frequency in long-term treatment with latanoprost in Japanese glaucoma patients.

It is unlikely that topical latanoprost induces retinal disorders, such as cystoid macular edema, in glaucomatous eyes with a normally functioning blood-ocular barrier.

Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.

ABSTRACT.Purpose: To investigate the influence of age, gender, refractive error, and optic disc size on optic disc configuration in Japanese normal eyes. Methods: Ninety-two eyes from 92 visually normal Japanese subjects (mean refractive error∫SD: ª1.26∫2.25 D, range ª8 D to π3 D) were examined using a confocal scanning laser tomograph, TopSS A . The following disc parameters were investigated: disc size, total or quadrant C/D area ratio and neuroretinal rim area, half-depth area, volume below, and average cup depth. Results: The disc diameter ( mean∫SD: 1.84∫0.16 mm) and disc size showed highly significant correlations with the C/D ratio (p∞0.001) and the neuroretinal rim area (p∞0.001). No other correlation was observed. Conclusion: These results indicate that the optic disc diameter and disc size have higher correlations with the optic disc configuration than age, gender, and refractive error in Japanese. These results are similar to those data reported for eyes of Caucasians or Afro Americans, and should be considered when optic discs are evaluated.

The incidence of iridial pigmentation by latanoprost ophthalmic solution in Japanese patients was higher than previously reported values in pigmented races.