Oncological diseases are one of the leading health problems both in the world and in Kazakhstan, second only to cardiovascular diseases. Hepatocellular carcinoma occupies the 8th place in the structure of oncopathologies, has an unfavorable prognosis and an unfavorable course. According to the WHO, more than 1.3 million people die each year from hepatocellular carcinoma (HCC). The incidence rate of HCC in Kazakhstan is up to 5.5 cases per 100 thousand of the population, and the mortality rate remains high (about 1000 people annually). In 2017, 82.3% of HCC patients died before the end of the year. Five-year survival in HCC does not exceed 18%, and postoperative recurrence is about 50%.

Considering the aging of the population, the combination of cardiovascular diseases with oncopathology is gaining more relevance. Liver cancer occupies the 6th place in the structure of the incidence of neoplasms and the 3rd place in mortality from all oncological diseases. One of the main methods of treating patients with liver cancer is chemotherapy and chemoembolization, which significantly affect the myocardium, developing cardiotoxicity. Myocardial damage is reflected in the development of heart failure, which subsequently is the main cause of death in cancer patients.