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Objective To study serum gonadotropin (FSH, LH) levels in cases of subclinical and overt hypothyroid women in reproductive age group. Material and Method Female patients of reproductive age group attending thyroid clinic of Acharya Vinoba Bhave Hospital were included in the study. Detail menstrual history was taken, and serum FSH and LH levels were estimated by radio immuno assay method. Result Eighty patients were included in the study, out of whom 46 (57.5%) had subclinical hypothyroidism and 34 (42.5%) had overt hypothyroidism. In subclinical hypothyroidism group the menstrual dysfunction which dominated in our study was oligomenorrhea (28.2%) followed by menorrhagia (17.39%). 39.13% had normal menstruation. In overt hypothyroidism group again it was oligomenorrhoea (23.5%) which was the principal menstrual abnormality followed by menorrhagia (17.64%). The percentage of females with normal menstruation was 47.05%. The levels of serum FSH and LH were significantly low in cases of both subclinical and overt hypothyroid women. They were significantly low when done between day 2 and 5 of the cycle. Conclusion Hypothyroidism decreases levels of serum FSH and serum LH. Subclinical hypothyroidism is one of the major etiological factors of infertility. Autoantibodies against thyroid should be searched for in cases of female patients with infertility.

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Background:The aims and objectives of this study were to determine whether maintenance tocolytic therapy with micronised progesterone (400 mg) in patients with arrested preterm labor, prolongs the latency period of gestation and to see the effect of prolonged latency period on fetal outcome in terms of birth weight and NICU admissions and maternal outcome in terms of prolongation to term gestation. Methods: Pregnant women who were arrested with acute tocolysis as evidenced by a 12 hour contraction free period were randomized into study and control groups. The study group received 400 mg of vaginal micronized progesterone daily, while the control group did not receive any drug. The patients were followed up till 37 completed weeks. Prolongation of pregnancy upto term and birth wt. and NICU admissions were noted. Results: 1) In the present study the mean period of gestation at delivery was significantly high in study group 37.51 ± 2.70 weeks as compared to that in control group 35.15 ± 2.72 weeks. This was statistically significant at 95% confidence interval by using student's t statistics. 2) In the present study, 42.00% babies in study group had birth weight more than 2.5 kg which was significantly higher than that in control group, in which 24.00% had birth weight more than 2.5 kg. Conclusions: We conclude that, maintenance tocolytic therapy with micronised progesterone (400 mg) up-to 37 weeks of gestation in patients with arrested preterm labor significantly prolongs the latency period and results in better perinatal outcome

Objectives: The aim of this study is to evaluate the efficiency and safety of intravenous iron sucrose complex and comparison with oral iron therapy in postpartum period in rural area. Materials and methods:It is a prospective, randomized, hospital-based clinical study carried out in over 150 patients, having Hb < 8 mg/dl after 24 hours of delivery. 600 to 800 mg iron sucrose has been given in divided doses, 200 mg on alternate day in 100 ml of normal saline to half of the patients whereas rest of the patients given 200 mg bd dose of ferrous sulphate by oral route for one month. Data was collected after 1st, 2nd, 3rd and 4th week for the hemoglobin estimation and assessment of the impact of intravenous iron sucrose treatment on the postpartum parameters. Results:The mean Hb was significantly increased in the intravenous iron sucrose group in 7 days (7.42 ± 1.04 gm/dl to 9.8 ± 0.76 gm/dl) of treatment but there was no change observed in mean Hb in the patients treated with oral ferrous sulphate. Women treated with intravenous iron sucrose has shown significantly higher Hb on day 7, day 15 and day 30 as compared to the women those were treated with oral iron (p < 0.0001). Conclusion:Overall intravenous iron sucrose appears to be an effective mode of treatment in postpartum patients with no serious side effects and associated with faster recovery in shorter duration of hospital stay than oral iron treatment.