Cancer related morbidity and mortality is a major health care concern. Developing potent anti-cancer therapies which are non-toxic, sustainable and affordable is of alternative medicine. This study was designed to investigate the aqueous natural extracts mixture (NE mix) prepared from common spices turmeric, ginger and garlic for its free radical scavenging potential and anti-cancer property against human breast cancer cell lines (MCF-7, ZR-75 and MDA-MB 231). Qualitative analysis of their bioactive constituents from turmeric, ginger and garlic were done using liquid chromatography-ESI-mass spectrometry (LC-ESI-MS/MS). To the best of our knowledge, NE mix with and without Tamoxifen has not been tested for its anti-cancer potential. We observed that the NE mix induced apoptosis in all the breast cancer cell lines, but it was more prominent in MCF-7 and ZR-75 cell lines in comparison to MDA-MB 231 cell line. The extent of apoptosis due to combined treatment with NE mix-Tamoxifen was higher than Tamoxifen alone, indicating a potential role of the NE mix in sensitizing the ER-positive breast cancer cells towards Tamoxifen. In support to MTT assay, cell cycle analysis, our RT-PCR results also prove that the NE mix 10 lg, Tam 20 lg and combination of NE mix 10 lg-Tam 20 lg altered the expression of apoptotic markers (p53 and Caspase 9) leading to apoptosis in all three cell lines. Our data strongly indicate that our NE mixture is a potential alternative therapeutic approach in certain types of cancer.

With the rapid advancements of the internet of things (IoT), several applications have evolved with completely dissimilar structures and requirements. However, the fifth generation of mobile cellular networks (5G) is unable to successfully support the dissimilar structures and requirements. The sixth generation of mobile cellular networks (6G) is likely to enable new and unidentified applications with varying requirements. Therefore, 6G not only provides 10 to 100 times the speed of 5G, but 6G can also provide dynamic services for advanced IoT applications. However, providing security to 6G networks is still a significant problem. Therefore, in this paper, a hybrid image encryption technique is proposed to secure multimedia data communication over 6G networks. Initially, multimedia data are encrypted by using the proposed model. Thereafter, the encrypted data are then transferred over the 6G networks. Extensive experiments are conducted by using various attacks and security measures. A comparative analysis reveals that the proposed model achieves remarkably good performance as compared to the existing encryption techniques.

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