Major guidelines have advocated early intervention with D2B <60-90 min. 2-4 In the wake of the COVID-19 pandemic, PPCI services have been reorganized in order to meet local or national strategies to cope T he coronavirus disease 2019 (COVID-19) pandemic has strained the global health system in an unprecedented manner. The effect on the delivery of health services is likely to be greater in time-sensitive services such as primary percutaneous coronary intervention (PPCI) for acute ST-segment elevation myocardial infarction (STEMI). Delay in treatment, including time from symptom onset to

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ICA cells constitute a delta-opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through beta(2)-AR/CGRP-R co-signalling, resulting in the activation of an anti-apoptotic pathway during ischaemia/reperfusion.