Within the limit of the present study, there was similar PD reduction, CAL gain, and bone fill at sites treated with PRF or PRP with conventional open-flap debridement. Because PRF is less time consuming and less technique sensitive, it may seem a better treatment option than PRP. However, long-term, multicenter randomized, controlled clinical trials will be required to know their clinical and radiographic effects on bone regeneration.

The PRF + 1% MF group showed greater improvements in clinical parameters, with greater percentage radiographic defect depth reduction compared to MF, PRF, or OFD alone in treatment of IBDs in patients with CP.

ATV as an adjunct to SRP can provide a new direction in the management of IBDs.

Locally delivered SMV provides a comfortable and flexible method to improve clinical parameters and also to enhance bone formation.

The periodontal health status of individuals with AD deteriorates with disease progression and was closely related to their cognitive function.