This study was undertaken to compare lipid profile of small for gestational age (SGA) and appropriate for gestational age (AGA) neonates. A total of 103 neonates were included; of which 63 were AGA and 40 SGA. Venous blood (2 ml) was obtained 2 h after the previous feed between 8 and 10 am on Day 3 or Day 4 of life and lipid profile was done. In AGA neonates, mean TC (total cholesterol), LDL (low density lipoprotein cholesterol), HDL (high density lipoprotein cholesterol) and triglycerides were 103.92 ± 47.79, 51.70 ± 23.03, 23.35 ± 11.41 and 187.62 ± 144.44 mg/dl respectively. AGA neonates had more TC and LDL than SGA neonates (P < 0.05). There was no significant difference in mean lipid profile between preterm and term neonates. Thus, normal lipid profiles in neonates in the index study are higher than that of the neonates from other parts of the world. The authors recommend further studies in India to outline normal values of lipid profile across various gestations and birth weights.

Cutaneous hypersensitivity to 2TU PPD is not comparable to that of 5TU PPD.

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Laron syndrome (LS) is a rare, genetic disorder inherited in an autosomal recessive manner. The disease is caused by mutations of the growth hormone (GH) gene, leading to GH/insulin-like growth factor type 1 (IGF1) signalling pathway defect. A 13-month-old, male child, born of second-degree consanguineous marriage presented with short stature (57 cm, below- 3 SD) with normal head size, mild motor developmental delay, micropenis and bone age of 9 months. Basal GH was 28.7 ng/ml (normal 1-13.6 ng/ml). IGF-1 was less than 20 ng/ml (normal up to 170 ng/ml). GH stimulation test done using clonidine revealed increased levels. Post stimulation levels at 30 min, 60 min, 90 min (ng/ml) were 29.3, 37.9, 29.3 respectively, which was suggestive of resistance to GH that is laron dwarfism. Treatment is focused on improving growth and generally includes injections of insulin-like growth factor 1 (IGF-1). This case is being reported for its rarity and early detection.

No abstract