The injected latex method was used to study the anatomy of the intramural segment in ten uteri. Another ten uteri were used for its histological evaluation. The intramural segment had an S-shaped course with double curves. Its length ranged between 0.9 and 1.7 cm. The lining epithelium showed variations at different levels with increase in cell density and number of cilia as the isthmus was approached. At the uterotubal junction, there were mucosal folds of endosalpinx directed towards the tubal lumen.
Twenty premenstrual endometrial biopsies were examined in 20 fertile women using combined conventional oral contraceptive pills (Anovlar‐1) for periods from 1–15 years using both SEM and light microscopy. Three types of endometria were detected. These were, irregular secretory, suppressed and atrophic endometria. Using scanning electron microscopy the first type showed few ciliated cells with weak cilia as well as collapsed non‐ciliated cells. The second type showed non‐ciliated cells with few signs of secretion. The third type showed rarely ciliated cells, flat secretory cells with no signs of secretions. The longer the duration of pill usage the more were the atrophic changes. Focal glandular proliferation was also detected.
The morphological changes in the ovaries of 20 normal and 20 post pill amenorrhea cases were studied via laparoscopy. Ovarian biopsies were taken in some of them to study the histopathological changes. Again endometrial biopsies were taken to study the endometrial picture in cases of post pill amenorrhea and to determine the stage of the menstrual cycle in the normal controls. The ovaries were morphologically active in 13 normal control cases encountered during the late proliferative and the secretory phase. The ovaries in all cases of post pill amenorrhea, on the other hand, were resting and inactive. Ovarian biopsies confirmed the morphological findings. Regarding the endometrial biopsies, histological patterns coincided with the ovarian morphological findings in the normal controls. While the endometrium was resting in 14 and atrophic in 6 cases of post pill amenorrhea. The significance of these results were discussed.
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