LOTFI, N.; KHAZAEI, M.; SHARIATZADEH, S. M. A.; SOLEIMANI MEHRANJANI, M. & GHANBARI, A. The effect ofCannabis sativa hydroalcoholic extract on sperm parameters and testis histology in rats. Int. J. Morphol., 31(1):82-86, 2013. SUMMARY:Cannabis Sativa is a multiuse herb in traditional medicine, its hydroalcoholic extract (10, 50, and 100 mg/kg) administered interaperitoneally for 14 consequent days to Wistar male rats resulted in significant decrease in progressive motility of sperm. Sperm count and seminiferous tubules diameter decreased significantly in comparison with control group. Also decrease in animal body weight in doses of 50 and 100 mg/kg was observed. Changes in testes weight and serum testosterone were not significant. Cannabis sativa extract has negative effect on sperm parameters such as motility, sperm count, and seminiferous tubules diameter.