These findings suggested that adding P-PRP or PRF to β-TCP graft substitute was not beneficial on new bone formation and regeneration, and P-PRP plus β-TCP or PRF plus β-TCP is not superior to β-TCP alone.

Background: The menopause is a physiological process that occurs and diabetes is a metabolic disease that has an increased incidence in advancing age in women. Aims & Objective: The purpose of the study to examine the effect of menopause and/or diabetes that causes pathophysiological status on parotid gland. Materials and Methods: Sprague-dawley 24 adult female rats (12 week old) were randomly, six rats in each group, divided into four groups; non-diabetic healthy (control), Diabetic (DM) group, Ovariectomized (OVX) group, Post Ovariectomy-Diabetes Induced (DM+OVX) group, respectively. To evaluate the results histopathological, histochemical and stereological analyses were performed. Results: Degenerative acini and duct cells with increased cytoplasmic lipid accumulation (vacuolization) in DM groups, polymorph nuclear infiltrations in OVX groups and extensive swollen nucleus with karyorrhexis and increased cytoplasmic lipid accumulation in serous acinus cells in DM+OVX group were detected. Furthermore the changes in the amount and character of secretion especially DM and DM+OVX groups and hypertrophic changes in the acinus epithelium in DM and/or the OVX groups were distinguished. Conclusion: The results revealed the effects of diabetes and ovariectomy on the cellular changes and pathophysiological processes of these changes in parotid glands. These findings may highlight to other pathophysiological processes of the role of the salivary glands associated with the pathogenesis due to diabetes and menopause. Additionally, correlated molecular mechanism of pathophysiological processes of DM and/or OVX on parotid gland, suggested further investigation.

The AR-induced pathological changes were diminished by desloratadine treatment. Thus, the new-generation antihistamine desloratadine may be used to treatment of AR patients who have xerostomia.

Objective: The menopause in elderly women is a physiological process where ovarian and uterine cycles end. Diabetes means higher blood glucose level that is a metabolic disease and has an increased incidence. The aim of the study was to examine the single or combined effects of menopause and diabetes that causes pathophysiological processes on submandibular gland on ovariectomy and diabetes induced rat models. Materials and Methods:Sprague Dawley twelve weeks old female (n=24) rats were divided randomly into four groups; Healthy control group (n=6), diabetic group (DM, n=6), ovariectomized group (OVX, n=6), post ovariectomy diabetes induced group (DM+OVX, n=6) individually. Histopathological, histochemical and stereological analyses were done in these groups.Results: Significant neutrophil cell infiltrations and myoepithelial cell proliferations, granular duct and seromucous acini damages and changes in the content of especially seromucous acini secretion in DM and/or OVX groups and distinctive interstitial and striated duct damages in post ovariectomy diabetes induced group were detected. Alterations ingranular ducts hypertrophic and in seromucous acini atrophic were determined in DM and/or OVX groups. Conclusion:The results revealed the pathophysiological processes that lead to morphological and functional alterations on the cellular level in submandibular glands. The molecular mechanisms related with pathogenesis of diabetes and menopause need further investigation.Keywords: Diabetes, gland, menopause, rat, submandibular ÖzetAmaç: İlerleyen yaş ile birlikte, menopoz, kadınlarda gözlenen overial ve menstrual sikluslarda azalma veya bitiş ile karakterize fizyolojik bir süreç ve diyabet ise insidansı artan yüksek kan şekeri seviyesi ile karakterize metabolik hastalıktır. Overektomi ve diyabet indüklenen sıçan modelleri submandibular bezi üzerinde menopozun ve diyabetin tek veya kombine etkilerinin neden olduğu patofizyolojik süreçle-ri incelemek amacı ile çalışma tasarlandı. Gereç ve Yöntem:Sprague Dawley on iki haftalık dişi (n=24) sıçanlar dört gruba randomize bir şekilde rastgele ayrıldı; Sağlıklı Kontrol Grubu (n=6), Diyabetik grup (n=6), Overektomize grup (n=6), Post Overektomize Diyabet İndüklenen Grup (n=6). Sonuçlar histopatolojik, histokimyasal ve stereolojik analizler ile değerlendirildi. Bulgular:Anlamlı nötrofil infiltrasyonları ve myoepitel hücre proliferasyonları, granüler kanal ve seromuköz hücre dejenerasyonları ve özellikle seromuköz asinusların salgısı içeriğindeki değişimler DM ve/veya OVX gruplarında, belirgin intersistiyel ödem ve çizgili kanal dejenerasyonları diyabet indüklenen post overektomize grup submandibular dokularında izlendi. Granular kanallarda hipertrofik değişiklikler, seromuköz asinuslarda atrofik değişiklikler DM ve/veya OVX gruplarında tespit edildi.Sonuç: Diyabet ve overektominin submandibular bezlerinde yol açtığı patofizyolojik süreçlere bağlı hücresel düzeyde morfolojik ve fonksiyonel değişiklikler gösterildi. Diyabet ve menopozun patogenezi ile ilişkili moleküle...

The non-antibiotic compound amlodipine may have a role in acute rhinosinusitis treatment through tissue protective, antioxidant and anti-inflammatory mechanisms.