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Benzydamine hydrochloride (BZY) is a non-steroid anti-inflammatory agent . It has been reported that about 50% of the administered drug in men and about 30% in rats were excreted in the urines, 1) but the conclusive information concerning its metabolites are not available. We studied the metabolic pathway of BZY by means of its strong fluorescence and identified some metabolites.BZY was administered orally at a dose of 200mg/kg to rabbits and the 24hr urine adjusted pH 5 was extracted with CHCl3. About 20% of fluorescence excreted in the urine was extracted into this fraction. After concentrating and dissolving the residue into a small amount of CHCl3, thin-layer chromatography (TLC) was carried out on Silica gel HF 254 (0 .

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