HEMS angiography can accurately assess peripheral arterial perfusion in surgical cases with ASO and AAA.

The HyperEye system can visualize any structural and functional failures. Our findings suggest that this device could become a useful tool for intraoperative graft assessment.

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Abstract:Dissolved organic matter (DOM) in seawater can be defined as the fraction of organic matter that passes through a filter of sub micron pore size. In this study, we have examined the effect of DOM of deep seawater (DSW) from Pacific Ocean on platelet aggregation and atherosclerosis progression. DSW was passed through a series of filters and then through an Octadecyl C18 filter; the retained substance in ethanol was designated as C18 extractable DOM (C18-DOM). Our studies showed that C18-DOM treatment inhibited platelet aggregation, P-selectin expression and activity of COX-1 significantly. C18-DOM increased the expression of anti-atherogenic molecule namely heme oxygenase-1 in endothelial cells and all these data showed that C18-DOM is exhibiting aspirin-like effects. Moreover our in vivo studies showed that C18-DOM feeding slowed remarkably the progression of atherosclerosis. Our study demonstrated a novel biological effect of oceanic DOM, which has several important implications, including a possible therapeutic strategy for atherosclerosis. Keywords:Deep seawater; Dissolved organic matter; Atherosclerosis; Cyclooxygenase-1 Atherosclerosis is a progressive disease of arteries, characterized by accumulation of lipids and fibrous elements and is responsible for up to 50% of deaths in the modern society [1].In the history of drug discovery, so far terrestrial resources have been targeted which led to the creation of various medicines. Recently, the trend has been switched on to the oceans, which is considered as a potential source for the next generation of drugs. In this study we have focussed on the dissolved organic matter (DOM) from deep seawater (DSW). DSW was collected from depths beyond 374 meters off (mesopelagic zone) the Cape of Muroto, facing the north-east Pacific Ocean, (Latitude 33.5º N and Longitude 134.10º E) using a DSW-drawing system, where intense up welling of DSW occurs due to the movement of ocean currents. Surface seawater was also collected from depth 5 meters off at the same location. The purpose of this research is to examine the effect and the mechanism of action of DOM in DSW on the progression of atherosclerosis. Materials and methodsPreparation of dissolved organic matter. We isolated DOM using a solid phase extraction method in which 1500 l of original SW was passed through a series of filters of size 50, 5 and 0.2 µm pore sizes, respectively (Y. S. Filter Japan) and then through an 3M Empore TM Octadecyl (C18) FF disc (90 mm) to retain the organic substance. The filtered DOM was dissolved in 25 ml of ethanol and was designated as C18-DOM. To prepare desalinated DSW, original DSW was passed through 50, 5µm filters, and then desalinated twice by a reverse osmosis membrane module using HR3155PI (Element Rabbit balloon injury model. Japanese Male White Rabbits (JMWRs) weighing 3-3.2 kg (Japan SLC, Inc., Shizuoka, Japan) were used in this study. All animal experimental protocols were followed in accordance with the Guide for the Care and Use of Laboratory Animals published by th...

The purpose of this study was to investigate the efficacy of landiolol hydrochloride, a short-acting  1 blocker, by initiating its administration at a low dose (5 g  kg -1  min -1 ) in patients with postoperative supraventricular arrhythmia. The efficacy of landiolol was evaluated in 38 patients who, after developing postoperative atrial flutter or fibrillation, with sinus tachycardia and 2 patients who had a history of paroxysmal atrial fibrillation with frequent atrial extrasystole. The heart rate and blood pressure before and 2 hours after the administration of landiolol were compared. A return to the sinus rhythm from supraventricular arrhythmia was noted in 89%. The heart rate was reduced from 137  26 bpm (before landiolol administration) to 93  18 bpm (2 hours after the start of the medication, P < 0.01). As an agent to correct an arrhythmic condition, landiolol successfully raised the systolic blood pressure from 108  24 mmHg (before medication) to 120  19 mmHg (2 hours after the medication was started, P < 0.05). Continuous intravenous infusion of landiolol at a low dose was found to be effective for postoperative supraventricular arrhythmia.