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Forty-nine patients with primary carcinoma of the liver were surgically treated at our hospital through 1961. Four cases with minute hepatocellular carcinoma which were subjected to liver resection were investigated.1. Twenty cases of this series underwent liver resection and their resectability was 41.7%. Of these 20 cases, 16 were concomitant with fibrosis or cirrhosis for back ground.Patients with such a cancer show poor prognosis and autopsy were performed on 10 cases.Histological findings showed marked proliferation of connective tissues and invasion of its fiber into the pseudolobules in the residual liver than the resected liver. Of 4 cases with minute hepatocellular carcinoma, 2 were positive serum AFP andHBs-Ag level and 3 were found tumor stain in hepatic arteriogram and low density area in hepatoscintigram.3. On gross specimen with minute cancer, all of them were of the single nodular type with capsule formation which were histologically found invasion of carcinoma. Tumors larger than 3.0cm in size revealed tumor necrosis, tumor thrombus in the portal vein and rupture of the hepatic capusules. Above findings indicated that those cases should be subjected to radical operation such as segmental resection or hepatic lobectomy.

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