Recent discussions on flood disasters concern the risk factors and causes between nature and anthropogenic activities. This disaster requires serious handling, which needs to be analysed, especially in areas affected by flooding with the Tegal Regency, Indonesia case study. The weakness of the existing mitigation efforts still needed comprehensive analyses, requiring a multi-criteria assessment based on GIS spatial analysis. The GIS method used is a raster calculator and weighted superimpose by setting several calculation variables from both physical and non-physical aspects to support the multicriteria spatial analysis. The results show that spatially, more than 30% of areas with a high-risk index are located in the downstream or coastal regions of Tegal Regency. However, the index of capacity and resilience in several flood-affected sub-districts is at an index above 0.5, so they have good strength to disasters such as the four sub-districts of Adiwerna, Bumijawa, Bojong, and Kramat. From the analysis results, land use change is the biggest problem that affects the number of the flood event. With this condition, the appropriate mitigation effort for Tegal Regency is strengthening the spatial planning policy and increasing the capacity, especially in disaster governance in a high-risk area. Thus, the vulnerability and hazard factors will be anticipated with high community participation in strengthening the capacity index.