The effect of catalyst on the yield of amine in the amination of three classes of arylzinc reagents with acetone oxime O-tosylate was investigated. Since they allowed the preparation of arylamines in excellent yields in the presence of a minimum amount of copper (I) or copper (II) compounds, the catalytic systems using copper (I) or copper (II) combined with a P-, N-or S-donor ligand were revealed to be the best catalysts for the electrophilic amination of arylzinc reagents with acetone oxime O-tosylate in the presence of DMPU.

Amines Q 0120Cosolvent-Promoted Electrophilic Amination of Organozinc Reagents. -By use of a cosolvent, the amount of CuCN and waste is reduced and the yields are improved.-(DASKAPAN*, T.; YESILBAG, F.; KOCA, S.; Appl. Organomet. Chem. 23 (2009) 6, 213-218; Fac. Sci., Ankara Univ., TR-06100 Ankara, Turk.; Eng.) -Bartels 41-061

In this study, we aimed to develop a simple and efficient method for the electrophilic amination of organozinc reagents. For this reason, 12 cosolvents were screened in the electrophilic amination of ordinary organozinc reagents. By the use of a cosolvent, an easily applicable and high-yielding method for the preparation of arylamines by electrophilic amination of arylzinc reagents was developed.

agents. -The amination of three classes of arylzinc reagents with acetone oxime O-tosylate is accomplished in the presence of a copper(I) or copper(II) catalyst and DMPU. P-, N-, or S-ligands have an accelerating effect on the reaction and cause in many cases a significant reduction of the amount of copper catalyst needed. -(DASKAPAN*, T.; KOCA, S.; Appl.