Mammary tumors are the most common tumor type both in women and in female dogs. In women, heritable breast cancers have been linked mutations in the breast cancer susceptibility gene BRCA2 and it contains eight BRC repeats in exon 11 that bind to RAD51. In this study, we investigated the sequence variations of BRC1-BRC8 and C-terminus of canine BRCA2 gene. From a total of 64 canine patients with mammary tumors, 31 mammary tumors with benign and malign carcinomas and the 3 normal mammary glands were used for the study. In this study, 19 SNPs of exon 11 of BRCA2 in canine mammary tumors were detected for the first time. The c.2383A>C (T1425P) SNP was found to be the most probable disease-associated nsSNP. Our findings suggest that T1425P variation in BRC3 to be the most probable disease-associated nsSNP and may affect RAD51 binding strength.

Objective:Oxidative stress plays a major role in the development of atherosclerosis. However, the relationship between oxidative stress and complexity and intensity of coronary artery disease is less clear. The aim of this study is to assess the relationship between oxidative stress markers and the complexity and intensity of coronary artery disease in patients with acute coronary syndrome (ACS).Methods:Sixty-seven consecutive patients with an early phase of ACS (<3 h) were included in this single-centre, cross-sectional, prospective study. Syntax and Gensini scores were calculated based on angiographic findings. Patients were divided into two CAD complexity groups according to their Syntax scores: low SYNTAX score (<22) and moderate to high SYNTAX score (>=22). Likewise patients were divided into two CAD severity groups according to the median Gensini score of 64: less intensive CAD with Gensini score (<64) and intensive CAD with Gensini score >=64. Blood samples were taken in 1 hour within administration in order to measure total oxidative status (TOS) and total antioxidant capacity (TAC) levels determined by Erel method. Oxidative stress index (OSI) was calculated by TOS/TAC.Results:There was no significant difference between the two SYNTAX groups for oxidative stress markers. Median TOS and OSI values were significantly high in the intensive CAD group (p=0.005, p=0.04, respectively). The Gensini score was positively correlated with TOS and OSI (p=0.003, p=0.02, respectively).Conclusion:Oxidative stress markers may be considered supportive laboratory parameters related to CAD intensity but not complexity in ACS patients.

This study was undertaken to determine the effects of storage period and egg weight of hatching eggs of Japanese quails on fertility, hatchability results. Eggs were obtained 150 females quails, all at 15 weeks of age. A total of 1942 hatching eggs were separated into 3 groups as light-weight (9.50-10.50 g), medium-weight (10.51-11.50 g), and heavy-weight (11.51-12.50 g). Based on storage period, eggs were divided into 5 groups as group 1 (0-3 days), group 2 (4-6 days), group 3 (7-9 days), group 4 (10-12 days), and group 5 (13-15 days). The influence of storage period on hatchability of fertile eggs and early, middle, and late period embryonic mortality rates was found significant (P<0.01). The effect of egg weight on fertility rate, hatchability of fertile eggs and early embryonic mortality was significant (P<0.05, P<0.01). The significant differences between storage period groups were observed in hatchability of fertile eggs. The differences between egg weight groups for fertility rate, hatchability of fertile eggs and early embryonic mortality was significantly higher in light weight group than the other egg weight groups. Results of this study concluded that a 12 day pre-incubation storage of hatching eggs of Japanese quails did not appreciably affect hatching parameters. Use of medium or heavy weight eggs for hatching may reduce early embryonic mortality rate. Gruppen (9,50 g; 10,50 und 11,50 g) und diese wiederum in fünf Untergruppen mit einer Lagerdauer von 0-3; 4-6; 7-9; 10-12 und 13-15 Tagen eingeteilt. Es konnte ein signifikanter (p<0,01) Einfluss der Lagerungsdauer auf die Befruchtungsrate, auf das Schlupfergebnis und die embryonale Mortalität während der gesamten Brutdauer nachgewiesen werden. Gleiches galt auch für den Einfluss des Eigewichtes auf das Befruchtungs-sowie das Schlupfergebnis, während das für die embryonale Mortalität nur für den ersten Brutabschnitt zutraf. Signifikante Unterschiede ergaben sich für den Einfluss der Lagerungszeit auf das Schlupfergebnis befruchteter Eier und die embryonale Mortalität in der frü-hen Brutperiode. Die schlechtesten Ergebnisse erzielten die Eier mit den geringsten Gewichten gegenüber den Eiern der schwereren Gruppen. Die Untersuchungen ergaben, dass eine Lagerzeit von bis 12 Tagen die Schlupfergebnisse nur unwesentlich beeinträchtigten und höhere Eigewichte die embryonale Mortalität verringerten.Schlüsselwörter: Eilagerungsdauer, Eigewicht, Schlupfrate, embryonale Mortalität, Wachtel Introduction The attention of numerous researchers has been focused on the relationship between egg weight and time of storage and the effect of these on hatching success and chick quality for many years (WILSON, 1991). A number of papers dealing with the

Endocan is a soluble proteoglycan, secreted by human vascular endothelial cells. Endocan is a marker for vascular pathologies and an important mediator of angiogenesis, strongly associated with inflammation, vascular endothelial dysfunction, and atherosclerosis. The relationship between coronary artery ectasia (CAE) and endocan has not been evaluated. We aimed to investigate this association. Fifty-four patients with isolated CAE without coronary stenosis and 30 controls with normal coronary angiogram were included in this study. Endocan plasma concentrations were measured using an enzyme-linked immunosorbent assay. Patients with isolated CAE had significantly higher levels of endocan compared to the controls (18.9 ± 7.3 vs 15.6 ± 3.6 ng/mL; P = .007). There was a significant correlation between endocan levels and severity of isolated CAE according to the Markis classification ( r = -.593, P < .001). Plasma endocan levels may reflect the presence and severity of isolated CAE, suggesting that endocan may be involved in pathogenesis of isolated CAE.

Seker, I., Bayraktar, M., Kul, S. and Ozmen, 0. 2007. Effect of slaughter age on fattening performance and carcass characteristics of Japanese quails (Coturnix coturnix japonica). J . Appl. Anim. Res., To determine the most economic slaughter age for male Japanese quails a total of 220 quail chicks were fed a standard feed up to 49 days. Rate of live weight gain started decreasing after 28 days of age. Feed consumption showed similar trend after d35. However, the feed required for each gram of weight gain exhibited steep increase after d42. Dressing percentage was the highest when the birds were slaughtered on d35. Considering these results the slaughter of male Japanese quails is recommended at 42 days of age.