No abstract

Immunoelectrophoresis of water soluble extracts of epidermis obtained from normal individuals showed only the presence of serum proteins. Watery extracts of psoriatic epidermis showed on immunoelectrophoresis in addition the presence of two distinct precipitation lines in the globulin region. These lines are apparently not related to any serum protein, leucocytes, erythrocytes or to bacterial antigens; their further identification is being attempted.

In the epidermis and scales from patients having psoriasis two proteins were found immunologically which were not present in healthy skin. These are low molecular weight and relatively stable skin proteins and were found to be characteristic of, although not specific for, psoriasis, as they were also present in other exfoliative skin diseases.