No abstract

The ATP: L-methionine-S-adenosyltransferase of rat cerebral cortex and cerebellum was found to be differentially responsive to solubilization by sodium deoxycholate. Furthermore, the cerebellar enzyme was markedly less sensitive to inactivation by deoxycholate and to storage at 4°C. The specific activity of the cerebellar enzyme was significantly higher and the two enzyme activities also exhibited differences in apparent K(m) values for L-methionine.

Y-P Lee et aZ( 1) observed that adminis- + T8The rats were trea,ted as follows: Group A received saline (euthyroid controls) ; group B received saline 4 wk after operation; group C received T, (100 pg/lOO g body wt) 4 wk after operation and was sacrificed 24 hr after injection; group D received TSH (20 m units/rat/day) for 2 days and was sacrificed on the fourth day; group E received TSH (20 m units/rat/day) for 6 days and was sacrificed on the seventh day; group F received TSH (100 m units/rat/day) for 6 days and was sacrificed on the seventh day.* Average (range).