This methodology involves synthesis of dibenzo xanthene tetraone by one pot multicomponent reaction of 2-hydroxy-1,4-naphthoquinone and pyrazole aldehyde in presence of p-toluenesulfonic acid (PTSA) as catalyst in ethylene glycol at 75-95 ºC. This protocol provides excellent yields (80-90%) involving simple workup procedures and purification techniques. By using several spectroscopic techniques the compounds were characterized.

An efficient protocol has been developed for the multicomponent synthesis of tetrahydrobenzo[g]quinoline-3-carboxylate derivatives using p-toluenesulfonic acid (p-TSA) as catalyst through one-pot four component condensation reaction of pyrazole aldehyde, Lawsone, β-ketoesters and ammonium acetate in ethanol. The synthesized compounds were characterized by spectroscopic techniques.

A catalyst-free synthetic strategy to chromene carbonitriles by Multi-Component Reaction of pyrazole aldehydes, 5,5-dimethylcyclohexane-1,3-dione and malononitrile with ethanol, at room temperature is reported. Screening of solvents and purification of the compounds were also performed. The newly synthesized novel compound’s (4H-chromene-3-carbonitriles) structures were authenticated by the spectral techniques viz. (1H , 13C)Nuclear Magnetic Resonance, FT-IR, and LC-MS analysis.

A new, efficient and catalyst-free synthetic strategy was developed for ten carbonitriles by the combination of pyrazole aldehydes and hydroxylamine hydrochloride in the presence of green solvent-glycerol. All the synthesized carbonitriles were confirmed from by 1H, 13C NMR and high resolution mass spectroscopies. The proposed synthetic process was simple, effective with high product yields and environmentally benign with mild reaction conditions.

A straightforward synthetic procedure for thioamides has been developed at 100 ºC using pyrazole aldehyde, a secondary amine, precipitated elemental sulphur and DMSO as solvent. The Willgerodt-Kindler reaction was successfully carried out by increasing the mole ratio of the precipitated sulphur and amine derivatives. The synthesized thioamides derivatives were characterized by 1H and 13C NMR, FT IR, HRMS spectrometric techniques. This method has various advantages, including high yields, a relatively rapid reaction time and the ability to operate in catalyst-free conditions.