Chemo-cycles of doxorubicin-nanocarriers are reported to be highly indicative of cell deformations and are a progressive indicator of acquired drug resistance.

Here we report nanocarrier-anticancer drug conjugates culpable of cellular deformations, critically evidenced through image-based analysis as a measure of karyoplasmic ratio (KR) and nuclear surface area (NSA). Multiwalled carbon nanotubes...

2D substrates promote cell attachment with lateral compression; 3DIS scaffolding restores the 3D cell structure allowing more realistic cellular-drug responses.

Designing nano-substrates (NS) that support three-dimensional (3D) cell growth using physico-chemical interventions mimicking cellular microenvironment is highly challenging. Here we report NS that assist 3D cell development (3D NS) using...

Control of the sub-cellular localization of nanoparticles (NPs) with enhanced drug-loading capacity, employing graphene oxide (GO), iron oxide (Fe3O4) NPs and sandwiched deoxyribonucleic acid (DNA) bearing intercalated anticancer drug doxorubicin...