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Morbid obez hastalarda kilo kaybının insülin direnci, bazal metabolizma hızı, antropometrik ölçümler ve tiroid fonksiyonlarına etkisiThe effect of weight loss on insulin resistance, basal metabolic rate, anthropometric measurements and thyroid functions in patients with morbid obesity

Aim: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM). We aimed to investigate the lipid profile in gestational diabetes. Material and Method:This study was included 127 GDM and 30 healthy pregnant women to control group, similar body mass indeks (BMI), gestational week and age group. Total cholesterol, high-density lipoprotein (HDL-C) plasma concentrations were measured by cholesterol enzymatic tests. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.Results: Triglyceride, total cholesterol, and LDL-C levels were found to be increased in pregnancy. However, it was not statistically significant. GDM compared with the control group in HDL-C were statistically significantly lower. When logistic regression was performed, HDL was lower than GDM control, regardless of age, BMI, gestational week. When Roc analysis was performed, it was seen that HDL <70 mg / dL GDM was predicted with 83% specificity and 64% sensitivity. Conclusion:Low HDL-C concentrations were significantly associated with an increased risk of GDM. Total cholesterol, LDL-C, TG values were not significantly elevated.

Prolaktin (PRL) hormonunun normalden daha yüksek miktarda salınımı olarak adlandırılan hiperprolaktinemi endokrinolojik tetkikler sırasında en sık rastlanılan patolojik durumdur. Hormon hipersekresyonuna neden olan hipofiz adenomlarının en sık karşılaşılan tipi prolaktinomalardır. Prolaktinomalar hemen her zaman benign olmalarına karşın, prolaktin hipersekresyonuna bağlı gonadal disfonksiyon yapmaları veya kitle etkisine bağlı çevre dokulara bası belirtileri oluşturmaları nedeni ile çoğunlukla tedavi gerektiren durumlardır.