Primary hepatic extranodal marginal zone B-cell lymphoma is extremely rare and remains an enigma with regard to clinicopathological features. Radiologic findings of primary hepatic extranodal marginal zone B-cell lymphoma are heterogenous. Therefore, the diagnosis is typically made by biopsy or after surgical resection. Due to a lack of evidence, there are no established standard therapeutic protocols or guidelines for this disease. Fortunately, these tumors tend to be indolent and respond well to various treatment modalities. Here, we report the case of a 72-year-old woman who was incidentally identified to have a solitary hepatic mass of 2.2cm in diameter. The mass was found to be a primary hepatic extranodal marginal zone B-cell lymphoma after surgical resection with suspected hepatocellular carcinoma. The patient did not undergo postoperative chemotherapy. There was no evidence of recurrence after 8 months.
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