Objectives : In this study, we select input factors for machine learning models to predict dissolved oxygen (DO) in Gyeongan Stream and compare results of performance evaluation indicators to find the optimal model.Methods : The water quality data from the specific points of Gyeongan Stream were collected between January 15, 1998 and December 30, 2019. The pretreatment data were divided into train and test data with the ratio of 7:3. We used random forest (RF), artificial neural network (ANN), convolutional neural network (CNN), and gated recurrent unit (GRU) among machine learning. RF and ANN were tested by both random split and time series data, while CNN and GRU conducted the experiment using only time series data. Performance evaluation indicators such as square of the correlation coefficient (R2), root mean square error (RMSE), and mean absolute error (MAE) were used to compare the optimal results for the models.Results and Discussion : Based on the RF variable importance results and references, water temperature, pH, electrical conductivity, PO₄-P, NH₄-N, total phosphorus, suspended solids, and NO₃-N were used as input factors. Both RF and ANN performed better with time series data than random split. The model performance was good in order of RF > CNN > GRU > ANN.Conclusions : The eight input factors (water temperature, pH, electrical conductivity, PO₄-P, NH₄-N, total phosphorus, suspended solids, and NO₃-N) were selected for machine learning models to predict DO in Gyeongan Stream. The best model for DO prediction was the RF model with time series data. Therefore, we suggest that the RF with the eight input factors could be used to predict the DO in streams.