The purpose of the study is to justify and prove the feasibility of taking regional measures to support small and medium-sized businesses by public authorities under current conditions of foreign economic sanctions. Based on the online survey methodology by the example of Volgograd region, the following problems and risks were identified which include: problems and risks for business entities in the region under sanctions pressure; the level of awareness of small and medium-sized businesses about the measures of state support; the level of satisfaction of small and medium-sized businesses with state support measures; the effectiveness of government support measures for business in the region under sanctions pressure. The study resulted in a comprehensive analytical insight. As small and medium-sized enterprises face various problems in the current conditions of foreign economic sanctions, therefore it is necessary to improve and develop (in view of successful experience of other regions) regional measures to support small and medium-sized businesses by public authorities. Particularly, this concerns maintaining reduced tax rates and rates for microfinance programs. A set of priority areas for leveling the main reasons why entrepreneurs cannot take advantage of measures to support business by public authorities in the context of foreign economic sanctions is proposed by the authors. The scientific novelty of the article is due to the rationale for prioritizing the use of regional support measures based on the methods of economic statistics to support small and medium-sized businesses by public authorities aimed at the development of financial (material) and information resources of business entities in the current conditions of foreign economic sanctions.