Propofol is a general anesthetic widely used in surgical procedures, including those in pregnant women. Preclinical studies suggest that propofol may cause neuronal injury to the offspring of primates if it is administered during pregnancy. However, it is unknown whether those neuronal changes would lead to long-term behavioral deficits in the offspring. In this study, propofol (0.4 mg/kg/min, IV, 2 h), saline, or intralipid solution was administered to pregnant rats on gestational day 18. We detected increased levels of cleaved caspase-3 in fetal brain at 6 h after propofol exposure. The neuronal density of the hippocampus of offspring was reduced significantly on postnatal day 10 (P10) and P28. Synaptophysin levels were also significantly reduced on P28. Furthermore, exploratory and learning behaviors of offspring rats (started at P28) were assessed in open-field trial and eight-arm radial maze. The offspring from propofol-treated dams showed significantly less exploratory activity in the open-field test and less spatial learning in the eight-arm radial maze. Thus, this study suggested that propofol exposure during pregnancy in rat increased cleaved caspsase-3 levels in fetal brain, deletion of neurons, reduced synaptophysin levels in the hippocampal region, and persistent learning deficits in the offspring.

No abstract

No abstract

Bullying is defined by American Psychological Association as an aggressive behavior which is intended to cause distress or harm and that involves an imbalance of power or strength between the aggressor and the victim. Bullying in the workplace is angering enough people these days to be fueling a nationwide grassroots legislative effort to force companies to draft and enforce policies aimed at stopping it. Requiring such policies, according to those pushing the legislation, is not an attempt to spawn lawsuits, but an effort to force organizations to deal with the problem. Bullying is blamed for unnecessarily creating high costs of turnover, insurance claims and thwarted productivity. Disruptive behavior has been observed in almost all members of the healthcare team from physicians and nurses to pharmacy, radiology, and laboratory staff members. Physician behavior, however, may have the greatest impact because of the position of authority that doctors hold as members of the healthcare team. A team member may, from fear of intimidation or patronization, withhold valuable or even critical input, such as a medication error or a breakdown in adherence to safety protocols. Hospitals, departments and individual personnel need to develop a higher level of awareness of the problem both in others and in them. Anti-bullying policies should be given a higher profile.

No abstract