Background: Insulin management with the basal bolus method is indicated in the diabetic patient admitted to the hospital ward. Few studies exist to suggest the best regimen to manage hyperglycemia in hospitalized patients. Material and metohds: It is a controlled, randomized, single-blind clinical trial. Forty-two participants were randomized into two groups, the first with a basal-bolus regimen with insulin glargine once a day and insulin lispro before each meal, the second with insulin three times a day with regular insulin before each meal. Results: No statistically significant difference was found in the daily glucose control goal. To assess safety, hypoglycemia events were analyzed by group, which did not show a statistically significant difference in both groups (p= 0.428). Conclusion: In safety, NPH insulin was similar in the presence of hypoglycemic events when compared to insulin glargine without presenting a significant difference between both groups, in terms of efficacy, no differences were found in achieving the conclusion that they can be used safely and safely. a lower cost.

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