Glomerular filtration rate (GFR) by means of creatinine clearence was measured in 42 newborn infants, whose gestational ages (GA) ranged from 26 to 41 weeks. Renal excretion of water, Na and K were also measured. A direct correlation was find between gestational age (GA) and creatinine clearence (r: 0.67). An inverse correlation ocurred between GA and Na fraccional excretion (r: -0.84), GA and plasma K concentration (r: -0.67). but no correlation was find among GA and K urinary excretion. Uiiiie's volume and water excretion were also inversely related to GA (r: 0.83 and r: -0.54 respectively). (Key words: Creatinine Cleaience. Glomerular filtration rate. Renal function. Term and preterm newborn infants. Water, Sodium, Potasium, excretion).El progresivo interes por el estudio de la funcion renal en el recien nacido de diferente edad gestacional y los cambios que sobre elia impone la vida extrauterina ha llevado, en los ultimos afios, a un conocimiento mas precise de la fisiologia del riflon en desarrollo.Las investigaciones realizadas, se han orientado fundamentalmente a evaluar la velocidad de filtracion glomerular y sus modificaciones en la vida postnatal 1 " 12 , asi como al estudio de algunas funciones del transporte de agua y electroHtOS 3 ' 4 ' 8 ' 9 -13-22.Lq avanzado hasta ahora, ha permitido un mejor enfoque terapeutico del recien nacido critico, especialmente del pretermino, contribuyendo a mejorar sustancialmente las tasas de morbimortalidad de este grupo.En el presente estudio, se analizan algunos de los parametros de funcion renal en recien nacidos normales de termino y pretermino antes de los dos di'as de vida, dada la falta de referencias nacionales sobre esta materia.
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