• The results were analyzed by analysis of variance and Pearson's correlation coefficient. RESULTS• Patients with relapsed calcium renal lithiasis present a greater BMD loss than those in the O or A groups.• Densitometry: T-score femur − 0.2 group O, − 0.5 group A, − 1.2 group B ( P = 0.001); T-score column − 0.6 group O, − 0.6 group A, − 1.3 group B ( P = 0.05).• A statistically significant negative correlation exists between values of β -crosslaps and T-score femur ( R = − 0.251; P = 0.009) and T-score column ( R = − 0.324; P = 0.001); thus, a higher concentration of β -crosslaps was accompanied by a lower value of the T-score and a greater loss of BMD.• A positive relationship is observed between β -crosslaps and osteocalcin ( R = 0.611; P < 0.001) and between calciuria and cocient β -crosslaps/osteocalcin ( R = 0.303; P = 0.001). CONCLUSIONS• A statistically significant relationship is shown between the loss of BMD and relapsed calcium renal lithiasis.• Determination of bone remodelling markers (i.e. osteocalcin and β -crosslaps) facilitates the diagnosis of osteopaenia/ osteoporosis in these patients. KEYWORDScalcium lithiasis, bone density, bone remodelling markers, bone densitometry What's known on the subject? and What does the study add? Hypercalciuria is related with bone mineral density loss.This study demonstrates the relationship between recurrent calcium nephrolithiasis and bone mineral density loss and their correlation with bone markers.Study Type -Aetiology (case control) Level of Evidence 3b OBJECTIVES• To show that a relationship exists between the loss of bone mineral density (BMD) and calcium renal lithiasis and that bone remodelling markers correlate with changes in BMD.• It is possible that many cases hypercalciuria are related to the increase of bone turnover and the predominance of bone resorption phenomena. PATIENTS AND METHODS• The present study comprised a transversal investigation in three groups: group O, without lithiasis; group A, with a single episode of lithiasis; and group B, with relapsed calcium renal lithiasis.• An analysis was made of body mass index; abdominal X-ray and/or urography and renal ultrasonography; osteocalcin and β -crosslaps bone markers; calcium and citrate concentrations in the urine; and femur and spinal column bone densitometry.

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Background. The end point of this study was to investigate the prevalence of MS in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone levels. Methods. This case-control study included 65 patients, 37 with erectile dysfunction, according to the International Index of Erectile Function (IIEF) from the Urology Department of San Cecilio University Hospital, Granada (Spain) and 28 healthy controls. The prevalence of metabolic syndrome was calculated according to ATP-III criteria. Hormone levels and acute phase parameters were studied in samples drawn. Results. The ATP-III criteria for MS were met by 64.9% of the patients with ED and only 9.5% of the controls (P < 0.0001, OR = 17.53, 95% CI: 3.52–87.37). Binary logistic regression analysis showed a strong association between patients with ED and MS, even after additional adjustment for confounding factors (OR = 20.05, 95% CI: 1.24–32.82, P < 0.034). Patients with hypogonadism presented a significantly higher prevalence of metabolic syndrome. Multiple linear regression analysis showed that systolic BP and CRP predicted 0.46 (model R 2) of IIEF changes. Conclusion. Chronic inflammation found in patients with ED might explain the association between ED and metabolic syndrome.

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