Objective: To compare the effect of laser irradiation at two different pulse settings and acid etching on the shear bond strength (SBS) of orthodontic brackets to enamel. Materials and Methods: Thirty-six premolars were allocated to three groups (n 5 12): (1) 37% phosphoric acid etching, (2) erbium-doped yttrium aluminum garnet (Er:YAG) laser etching with medium-short pulse mode (MSP; 100 ms, 120 mj, 10 Hz, 1.2 W), and (3) Er:YAG laser etching with quantum-square pulse mode (QSP; 120 mj, 10 Hz, 1.2 W). Metallic brackets were bonded with Transbond XT. After photopolymerization, the samples were subjected to 5000 thermal cycles and debonded with a universal testing machine, and the SBS values were recorded. Surface morphology was evaluated with profilometric examination, scanning electron microscopy, and atomic force microscopy. The adhesive remnant index (ARI) was evaluated to assess the remaining adhesive. Results: The results of SBS testing were analyzed by one-way analysis of variance and Tukey honestly significant diffference tests. The mean SBS values of QSP and MSP laser groups were 11.80 6 2.7 MPa and 10.10 6 4.5 MPa, respectively, and the QSP group demonstrated significantly higher SBS (P , .01) than that of the acid-etched group (6.6 6 2.4 MPa). No significant difference was observed between the SBS values of the two laser groups (P , .05). The difference between the ARI scores of the laser groups and the acid-etched group was statistically significant (P , .05). Conclusion: Laser etching at MSP and QSP modes present successful alternatives to acid etching; however, long-term clinical studies are required to verify clinical success. (Angle Orthod. 2013;83:973-980.)