INTRODUCTION: In this work, a simple and rapid liquid chromatographic method for the simultaneous determination of irbesartan (IRBE) and hydrochlorothiazide (HCT) was developed and validated using reverse phase high performance liquid chromatographic (RPLC) method. METHODS: Experimental conditions such as; different buffer solutions, various pH values, temperature, composition of the mobile phase, the effect of flow rate were optimized. RESULTS: The developed RPLC method for these antihypertensive agents was wholly validated and IRBE was detected in the linear range of 0.1-25 μg.mL-1 and HCT was detected in the linear range of 0.25-25 μg.mL-1. Moreover, the suggested chromatographic technique was successfully applied for the determination of the drugs in pharmaceutical dosage forms with LOD values of value of 0.008 µg.mL-1 for IRBE and 0.012 µg.mL-1 for HCT. DISCUSSION AND CONCLUSION: It is believed that the proposed rapid analyses method of these antihypertensive drugs can be easily used and applied in pharmaceutical companies where the analyses time is important.