Antiepileptic drug (AED)-induced hypersensitivity reactions(HSR) which are reported to be more common in children, present with a variety of clinical manifestations ranging from benign maculopapular exanthems to severe delayed reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Drug Reaction with Eosinophilia and Systemic Symptoms(DRESS) and also organ-specific disease such as agranulocytosis and drug-induced liver injury. 1 Immediate-type HSRs such as urticaria/ angioedema or anaphylaxis are very rare with AEDs. Delayed reactions are more commonly seen with aromatic AEDs like phenytoin and carbamazepine than the new generation or non-aromatic AEDs. 1 Levetiracetam is an increasingly used new non-aromatic AEDs and reported to have a safer tolerability profile in daily practice. 2 Here, we report an adolescent case of anaphylaxis due to levetiracetam, in order to point out that new AEDs can result in HSRs and also, severe immediate reactions should be expected Case ReportA 15-year-old girl with no previous diagnosis of epilepsy presented to the pediatric emergency department with a history of two seizures in the same day. Later in the emergency department, the patient experienced another seizure with jaw-locking, nystagmus, spasms in legs and arms