Background & Aim: Since observance of ethical standards is an effective factor for improving the performance of nurses in providing quality care. This study was conducted with the aim of evaluating the ethical sensitivity of nurses working at Shahid Madani Hospital in Khorramabad in the spring of 2017. Materials & Methods: This cross-sectional study was performed on 200 nurses working in Khorramabad city at Shahid Madani Hospital. Samples were selected through simple random sampling. Data were collected using a demographic questionnaire and a nurses' ethical sensitivity questionnaire for decision making. Collected Data was analyzed by SPSS software version 16 and descriptive and inferential statistics. Results: According to the reported results, 19.5% of nurses had a low moral sensitivity, 77% had moderate moral sensitivity and 3.5% had high moral sensitivity. The highest scores were related to knowledge about the relationship with the patient 63.33±15.45 and the lowest score was for professional knowledge of nurses 52.69±13.6. Conclusion: According to the findings of this study, it was found that nurses had moderate moral sensitivity. It is suggested to nursing managers to develop appropriate programs to increase nurses' moral sensitivity in the system of health care in the country.