Background: Drug abuse issue is an internationally serious and important problem viewed from different economic, social, physiological, and psychological angles. It is a multidimensional phenomenon which has attracted the attention of many psychologists, consultants, and social workers. Objectives: The current study aimed to compare the level of adherence to the Islamic lifestyle among addicted and non-addicted young inmates in the prisons of Alborz province. Materials and Methods: The research method of the current study was causual-comparative, and the implementation method was survey. Data were collected by Kaviani`s Islamic lifestyle questionnaire (2011). The statistical population and sampling method: All inmates of the Alborz province prisons formed the population of the study, and 250 subjects were selected by multi-stage cluster method from the population. Results: One-way analysis of variance (ANOVA) showed a significant difference in the level of adherence to the Islamic lifestyle (F = 10.52, Df = 2) among three groups of addicted and non-addicted inmates, and the personnel of the prisons. T-test of two independent groups also showed significant difference in the level of adherence to the Islamic lifestyle between women and men (t =-2.39, P ≤ 0.05). Conclusion: A significant difference was observed among three groups of addicted and non-addicted inmates, and the personnel of the Alborz province prisons in the level of adherence to the Islamic lifestyle, this difference was also significant in terms of sex.