Aim: There is much evidence of an association between cancer and irisin that is an adipokine. This study researched on the relationship between prostate cancer (PCa) and irisin levels, and whether irisin can be used as a biomarker in the diagnosis of PCa. Materials and Methods: For the study groups, 50 primary PCa patients and 30 healthy male subjects were included in the PCa and healthy control groups, respectively. All volunteers in the healthy control group were screened for prostate cancer and other malignancies and chronic diseases. Volunteers who were determine to be completely healthy were included for healthy control group. In the serum samples of the subjects were measured free PSA, total PSA and irisin levels. Irisin levels were compared separately in terms of the Gleason scores and T stage. In addition to intergroup comparisons, the ROC curve for the irisin was plotted and power analysis was performed. Results: Free and total PSA levels in the PCa group were significantly higher compared to the healthy control group (p<0.05). In addition, irisin levels in the PCa group were significantly lower than in the healthy control group (p<0.05). There was no significant difference between irisin levels in the groups classified in terms of Gleason scores (p>0.05). When the cutoff value was taken as 8.1, the sensitivity and specificity of irisin for PCa were as 80.5% and 90%, respectively. Conclusion: The results of this study indicate that the levels of irisin in the PCa group are considerably reduced and irisin may be used as a biomarker as well as free and total PSA.

Benign prostatic hyperplasia (BPH) is one of the most common causes of bladder outlet obstruction in me n. In this study we aimed to evaluate the elasticity of the bladder by Acoustic Radiation Force Impulse (ARFI) elastography in BPH patients. Fifty benign prostate patients were included in the study. After evaluation of patients in the outpatient clinic. A RFI elastography was performed with full bladder. Elastography was performed separately on the anterior, right and left walls of the bladder. Then the patient underwent uroflowmetry. The maximum flow rate and post-mix residual values in uroflowmetry were recorded. The mean age of the patients was 45.6 ± 3.77 The average of bladder anterior wall elasticity 3.39 ± 0.89, Bladder left wall elasticity 2,69 ± 0,82 and Bladder right wall elasticity was 3.69 ± 0.89.The mean prostate size 52.58 ± 24.16 The average of Qmax11.96 ± 4.85 The mean of PMR 77.8 ± 59.6 and mean of prostate elasticity was 2.97 ± 1.1 Urinary bladder wall elasticity with ARFI can be a diagnostic indicator for bladder outlet obstruction due to BPH.

Ürogenital travmalar tüm travmaların %10'unu oluşturmaktadır. Bu travmaların önemli bir kısmını ise alt üriner sistem yaralanmaları oluşturmaktadır. Bu makalede alt üriner sistem yaralanmaları ile ilgili deneyimlerimizin paylaşılması amaçlandı. Gereç ve Yöntemler: 23 Mart 2011 ile 1 Nisan 2016 tarihleri arasında acil polikliniğine başvuran alt üriner sistem ve penis yaralanmaları hastalarının dosyaları retrospektif olarak hastanemiz otomasyon sistemi taranarak incelendi. Hastalar demografik özellikler, etyoloji, eşlik eden yaralanma ve cerrahi sonuçları açısından değerlendirildi. Bulgular: Belirtilen tarihler arasında acil polikliniğine 14 mesane, 38 üretra ve penis yaralanması olmak üzere toplam 52 hastanın başvurduğu görüldü. Mesane yaralanması olan 14 hastanın 10'u erkek iken dördü kadın idi. Üretra ve penis yaralanması olan tüm hastalar erkek iken bu hastaların 22'sinde üretra 14'ünde penis yaralanması, ikisinde ise hem penis hem üretra yaralanması mevcut idi. Kavernozum yaralanması olan hastaların 12'sinde cinsel ilişki nedeniyle penil fraktür gelişmişti. İkisinde ise düşme sonra penil fraktür gelişmiş olduğu görüldü. Sonuç: Acil servise travma nedeniyle başvuran hastalarda alt üriner sistem ve penis yaralanmaları da olabileceği göz önünde bulundurularak dikkatli olunmalıdır.

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