Various methods have been proposed for the evaluation of reservoir rock wettability. Among them, Amott–Harvey and USBM are the most commonly used approaches in industry. Some other methods, such as the Lak and modified Lak indices, the normalized water fractional flow curve, Craig’s triple rules of thumb, and the modified Craig’s second rule are based on relative permeability data. In this study, a set of capillary pressure curves and relative permeability experiments was conducted on 19 core plug samples from a carbonate reservoir to evaluate and compare different quantitative and qualitative wettability indicators. We found that the results of relative permeability-based approaches were consistent with those of Amott–Harvey and USBM methods. We also investigated the relationship between wettability indices and rock quality indicators RQI, FZI, and Winland R35. Results showed that as the rock quality indicators increased, the samples became more oil-wet.