ultiple gliomas have been classified as multicentric if they arise independently in more than one parenchymal areas without any continuity and as multifocal if they arise in a primary parenchymal focus and spread to other cerebral areas. 1-4 Multiple cerebral tumor-like lesions are usually considered as a metastatic disease in patients with systemic cancer. However, in some patients, multiple tumor-like brain lesions may mimic multicentric gliomas or multiple metastases and they may be mistreated. 5 We report a patient with multicentric glioblastoma mimicking demyelinating plaque disease. CASE REPORT A 66-year-old male patient presented to the hospital with severe frontal headache progressing for the last two months. In his neurological examination, motor dysphasia was detected. He had a history of radical prostatec