The purpose of the study was to investigate the effect of enteric oxygen therapy on helicobacteriosis in the rehabilitation of children with chronic gastroduodenal pathology. 286 children and adolescents aged from 6 to 15 years with chronic gastritis, duodenitis, gastroduodenitis, gastric ulcer and duodenal ulcer were examined. To study the effectiveness of  the recommended rehabilitation program, all patients were also divided into two rehabilitation groups, identical in age and clinical forms of the underlying disease. Determination of Helicobacter pylori (Hp-carrier) was performed using the breath test.Studies have shown that after the conventional course of eradication therapy, helicobacteriosis reduced to an average of 23.6%, but was not completely cured, or reinfection was observed. After primary rehabilitation, enteric oxygen therapy in combination with a prophylactic course of eradication therapy, a decrease in the Hp-carrier ratio on average by 14.3% was observed.It was concluded that patients with chronic gastroduodenal pathology after a course of standard treatment need rehabilitation therapy. After a comprehensive rehabilitation program there was observed a significant reduction in Hp-carrier up to 5 times, on the background of an improvement of laboratory and endoscopic test results.

The study features of premorbid background and the most significant predictors of the development of chronic gastroduodenal pathology in children and adolescents of school age. Materials and methods. The results of screening questioning of schoolchildren with chronic gastroduodenal pathology (CGDP) - n=286, and practically healthy schoolchildren - n=1023, from 6 to 15 years agо. The survey conducted according to the questionnaire developed by us, which includes 24 questions. The relative risk (RR) calculated using traditional statistical formulas with a confidence interval limit 95% CI (confidence interval). Results. In this study, it was found that the main nutritional reason for the development of СGDP in schoolchildren is a malnutrition - 69.2%, RR=2.25 (CI=1.81-2.79), and food for fast food - 65.0%, RR=4.19 (CI=3.45-5.09). The least observed was the abuse of spicy food - 4.9%, RR=1.24 (CI=0.80-1.91). The 42.7% of patients were constantly in a state of heightened psychoemotional stress - RR=1.6 (CI=1.32-1.93). Helicobacter pylori (HP) - infection was diagnosed in 57.7% of patients - RR=4.84 (CI=4.04-5.79), 29.0% of patients underwent acute intestinal infections - RR=2.74 (CI=2.29-3.27), and 62.3% had a history of hereditary burden of chronic diseases of the gastrointestinal tract - RR=1.65 (CI=1.34-2.02) Conclusion. The most significant predictors and premorbid backgrounds for the development of СGDP in schoolchildren are HP-infection (RR=4.84; CI=4.04-5.79; RRR=3.84), food for fast food (RR=4.19; CI=3.45-5,09; RRR=3.20) with the development of overweight and obesity (RR=3.64; CI=2.97-4.47; RRR=2.64), the presence of chronic foci of infection (RR=2.58; CI=2.05-3.23; RRR=1.58).

Introduction. Pathologies of thyroid dysfunction associated with iodine deficiency remain one of the urgent problems throughout the world and are mainly associated with natural iodine deficiency in places where about 30% of the world’s population lives.Objective. Study of the dynamics of thyroid hormones in infants born from mothers with diffuse endemic goiter.Materials and methods. A retrospective study of 68 infants from mothers with diffuse endemic goiter (DEG) was carried out. Research methods included: analysis of anamnestic data, palpation, and ultrasound in mothers, with a study of the level of thyroid hormone in newborns and parturient women.Results. Infants from mothers with DEG have characteristic changes in the level of thyroid hormones in the blood, in particular, in the cord blood, the level of thyroid-stimulating hormone (TSH) is 22.4% higher than in the control group (p < 0.05). The difference between free triiodothyronine (T3) and thyroxine (T4) is on average lower by 8.6% and 4.3%, respectively, (p < 0.05 and p < 0.1). On the 3rd day of life, these fluctuations persist, and the level of TSH in the peripheral blood exceeded up to 20.9%, but there were no pronounced clinical signs of congenital pathology associated with the thyroid gland. At the same time, in the first months of life in infants, there is a lag in weight gain by an average of 9.6% about practically healthy newborns.Conclusion. In infants born to mothers with DEG, there is an increase in the umbilical blood level of TSH up to 22.4% about practically healthy newborns, with a simultaneous decrease in T4 to 4.3%, T3 to 8.6%, without pronounced clinical signs of congenital pathology. In these children, in the first months of life, there is a lag in physiological weight gain of up to 9.6%, which should be taken into account when managing children in an outpatient setting.

Introduction. At the same time, in the last decade, pediatricians have increased interest in the study of the therapeutic effect of bacteriophages in infectious diseases of rhinolaryngological organs.Objective. The analysis of results of the use of inhalation bacteriophage therapy in children with acute tonsillitis, on an outpatient basis.Materials and methods. Examined 212 children from 4 to 15 years old with acute tonsillitis. Conducted general clinical research, pharyngoscopy, bacteriological examination of a smear of tonsils. Bacteriophage therapy carried out using the Pyobacteriophage complex liquid (PCL).Results. In the course of an objective clinical analysis, on the day of seeking outpatient care, patients noted asthenovegetative disorders in all patients (100%), in the form of general weakness (96.8%), loss of appetite (94.8%), and headache (92.5%). During the examination, cervical lymphadenopathy (98.6%), tonsil hyperemia and hyperplasia (98.1%), and exudates (48.1%) noted. It revealed that the main causative agents of acute tonsillitis in children were the bacteria Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae, with different relative proportions (from 24.2% to 59%). Inhalation bacteriophage therapy carried out from the first days of the disease. Against the background of therapy, it was noted - a decrease in swelling in the tonsils by 2-3 days with a decrease in general intoxication signs. On the 6th day from the beginning of bacteriophage therapy, asthenovegetative disorders stopped 2.2 times faster in relation to patients who did not receive bacteriophage therapy, against the background of a decrease in the manifestation of objective clinical signs of the disease.Conclusion. The use of inhalation bacteriophage therapy as part of the conservative treatment of acute tonsillitis in children contributes 1.4 times to the fastest relief of the acute period and an improvement in the subjective assessment of well-being is 25% higher concerning the comparison group.

A review article is devoted to the analysis of scientific and literary data published over the past 10 years, devoted to the problem of studying the role of Helicobacter pylori in the development of iron deficiency anaemia in children and adolescents. Comparative data of domestic and foreign scientists on the mechanism of exposure of Helicobacter pylori (НР) to the pathogenesis of resistant iron deficiency anaemia in children are given.It was determined that the development of iron deficiency anaemia in children with HP infection is influenced by many mechanisms, therefore, in the treatment of children with this pathology, the appointment of anti- HP bacterial therapy with ferrotherapy, taking into account age-related characteristics and needs, is justified.