Osteosarcoma (OS), the most common type of primary malignant bone tumor, is defined by the presence of malignant mesenchymal cells producing osteoid or immature bone. The peak incidence of the most frequent type of OS, i.e., high-grade central OS, occurs in the second decade of life during the adolescent growth spurt. Most patients suffer from the pain and swelling in the involved region and, usually, seek medical attention. Diagnosis is carried out by conventional radiographs, computed tomography, and magnetic resonance image (MRI). In addition, three-phase bone scans, thallium scintigraphy, dynamic MRI, and positron emission spectroscopy are new innovative promising tools. OS can be treated with surgery, radiotherapy, and chemotherapy. There is a clear need for newer effective agents for patients with OS, especially for patients who afflicted with metastatic and recurrence tumor. Monoclonal antibodies directed against OS may prove useful as treatment, either for drug delivery or for radiopharmaceuticals.

Background: Mosquito borne diseases pose significant burden to the community which can be prevented through right knowledge, attitude and practice of it. Objective: To study the knowledge, awareness and practices of school children about mosquito borne diseases. Materials and Methods: A predesigned, semi structured proforma was filled out from 261 students of 9th to 12th standard of Malwa region. Data was entered in Microsoft excel and percentage of answers were calculated. Results: All students knew something about the mosquito borne diseases. Most of the students (>80%) knew about the malaria and dengue. Very few students were having knowledge that Japanese encephalitis, yellow fever and filariasis are spread though mosquito. 68.2% of students knew fever with chills as symptoms of mosquito borne diseases. More than 85% of students told that mosquito borne diseases can be prevented either through individual protection or through community level protection, supported by government. Conclusion: The awareness regarding malaria was good among students of Malwa region but same was lacking about other mosquito borne diseases.

Introduction: Nearly 60-80% of the term and preterm neonates are affected due to rise in bilirubin levels during early postnatal days, and causes readmission of the neonate sometimes with severe jaundice, which can be reduced if neonatal hyperbilirubinemia can be predicted early. The study was conducted to evaluate the predictive values of cord blood albumin and bilirubin for neonatal hyperbilirubinemia and to evaluate the better predictor between them. Method:  In this hospital based observational study, 152 healthy term newborns with birth weight more than 2.5 kg were included. Assessment of cord blood haemoglobin, blood group, albumin and bilirubin levels was done. Follow-up for first consecutive five days after birth was done and assessed daily to look for evidence of jaundice, sepsis or any other illness. Serum bilirubin was evaluated at 72-96 hours of life in all neonates and was done early, if clinically indicated. Receiver’s Operating Characteristics curves were used for calculating the cut-off values of cord blood albumin and bilirubin in relation to hyperbilirubinemia. Result: The cut-off values obtained for albumin and bilirubin of cord blood was < 2.56 mg/dL and >2.33 mg/dL respectively at optimum sensitivity and specificity. Cord blood bilirubin was found to be highly sensitive for early recognition of significant neonatal hyperbilirubinemia as compared to cord blood albumin and can be used for screening purpose. Conclusion: Cord blood albumin and bilirubin can be used for negating the development of NNHB, but for screening purpose, cord blood bilirubin is more predictive of neonatal hyperbilirubinemia.

Introduction: Breast milk is planned for nursing young ones and therefore considered as nature’s most precious gift to humankind. However, despite strong evidences in support of breastfeeding, its prevalence has remained low worldwide. Objective: The objective of this study is to explore the knowledge, attitude, and perception toward breastfeeding among primigravida mothers and factors determining them. Materials and Methods: The study was conducted over 18 months on primigravida mothers admitted in postnatal care ward of tertiary care center of a medical college. Questionnaires were filled by mothers of newborns about various domains such as initiation of feeding, latching, maternal position during breastfeeding, prelacteal, colostrum, exclusive breastfeeding (EBF), and feeding at public places. Results: A total of 260 women aged 21–25 years were included in the study. Most of them were the housewives (81.5%), Hindu (95.4%), living in joint family (55.8%), and living in urban area (73.8%). About 90.4% initiated breastfeeding immediately after delivery and mothers have good knowledge on breastfeeding (81.1%). Mothers living in joint family had significantly more knowledge about the EBF and importance of colostrum. The source of their knowledge regarding breastfeeding was mostly medical staff (95.4%). Conclusion: The present study found that mothers had satisfactory knowledge regarding breastfeeding. Proper counseling and all level of support should be given to primigravida mothers, and breastfeeding practices can be increased by strengthening the existing program through media support and by removing social taboo regarding breastfeeding.

Background:Brainstem gliomas account for approximately 25% of all posterior fossa tumors. In pediatric age group, it constitutes about 10% of all brain tumors. Brainstem glioma is an aggressive and lethal type of malignancy with poor outcome despite all treatments.Aim:We studied the incidence and treatment outcome in pediatric patients with brainstem glioma depending on their tumor volume presenting in our institution in last 5 years. Brain tumors comprised 2.95% of all cancers and brainstem gliomas were 8% of all brain tumors.Materials and Methods:Nine pediatric patients were included in this analysis, who were treated with localized external radiotherapy 54–59.4 Gy along with temozolomide 75 mg/m2 during the whole course of radiotherapy.Results:The median survival in all these patients was 20 months and the overall 2 years survival is 44.4% (4/9). The median survival of patients with primary disease volume <40cc is 26 months whereas when the volume is more than 40cc the median survival is 13.5 months as calculated by Chi-square test.Conclusion:As this study includes a small number of patients with unknown histology and treated on the basis of magnetic resonance imaging findings, no definite opinion can be given as some patients may have a low-grade tumor. More studies are required to establish the relation of size of the tumor with survival.