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Wadi Natash area is located in the southern part of the Eastern desert of Egypt. It has a great importance for containing accumulations from the radioactive minerals of Uranium, Thorium and Potassium. An integrated potential study was carried out on the study area with the aim of locating depths to causative bodies with sufficient magnetic susceptibility that may represent magmatic intrusions with relation to the radioactivity location and delineate the subsurface structures affecting the area. Both magnetic and Bouguer data as well as radiometric data were interpreted rapidly for source positions and depths using Euler deconvolution, Werner deconvolution and 3D modeling techniques. The results deduced from the trend analyses show that the major fault trend affecting the area have NNW-SSE (Red Sea-Gulf of Suez trend) direction intersected by the less predominant NNE-SSW(The Gulf of Aqaba-Dead Sea trend) and WNW-ESE (Najd Fault System) fault trends. The causative bodies were imaged at depths ranging from 0.3 km to about 1.5 km. The depths along the interpreted profiles display discontinuities in potential field markers due to presence of the NNW-SSE fault trends act as pass channels for the hydrothermal solutions.It can be stated that the radioactive mineral accumulations were caused by the hydrothermal solutions rich with radioactive minerals as a result of intruding Natash volcanic to the granitic rocks. The Qouseir clastics and the Nudian sand stone were affected by these solutions and show a positive response for the radioactive minerals.