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Using pieces of rat pancreas incubated bation medium to 3.0 mg./ml. without in Krebs-bicarbonate buffer containing addition of octanoate produced a slight-0.6 mg. glucose/ml., it has been found ly smaller though significant (p < .05) that addition of 3.0 mM. octanoate to increase in insulin release (2.96 t 0.96 the incubation medium significantly (p &J./mg.) above control levels. In con-< .OOl) increased insulin release above clusion, octanoate is capable of directly control levels by 4.94 + 0.89 PU. insustimulating additional release of insulin lin/mg. of pancreatic tissue. Increasing by the beta-cells of the pancreas. (Methe glucose concentration in the incu-tabolism 16: No. 5, May, 482-484, 1967) R ECENTLY, it has been demonstrated that intravenous administration

No abstract

Intravenous infusion of 500 ml. 6% polyvinylpyrrolidone (P.V.P. (Mw 40,000) in isotonic saline solution over a 2-hour period significantly diminished platelet adhesiveness in eight subjects from 27% before infusion to as low as 10% at the end of the infusion. 5 hours after the end of the infusion, platelet adhesiveness was still significantly reduced (16%). The addition of P.V.P. to citrated blood in vitro significantly decreased platelet adhesiveness. Both in vivo and in vitro, the platelet-count was not significantly altered by P.V.P. The in-vivo change in platelet adhesiveness is similar to that reported by others with dextran-a plasma expander that differs chemically from P.V.P.