Management information systems (MIS) and its support to "sustainability"are outlined with a special emphasis to small and medium enterprises (SMEs) development. An overview and strategy of a sustainable MIS(SMIS) is described as a measuring, managing and innovative tool for todays' sustainable SMEs (SSMEs). SSMEs and their advantage over other SMEs and multinational companies (MNCs) in the light of sustainability factors are detailed. Some existing challenges along with few limitations of SMIS are presented, along with fourrecommendations for better effectiveness of SMIS.