The successful implementation of information technology (IT) is largely determined by the level of acceptance of each individual user. Therefore, understanding and prediction are needed to increase user acceptance by changing the nature of the system and the implementation process used. This also applies to the Sistem Informasi Enterprise Soetomo untuk Transparansi dan Akuntabilitas (SIESTA) developed by RSUD Dr. Soetomo, which until now has never measured the level of acceptance of the system. This study aims to determine the factors that influence the acceptance of the modul Kepegawaian SIESTA using the UTAUT2 model so that the research results can be used by RSUD Dr. Soetomo Surabaya in implementing other SIESTA modules. The sampling method taken is the disproportionate stratified random sampling method using 5% error tolerance and obtained a total sample of 359 respondents. The data analysis uses Structural Equation Modeling-Partial Least Square (SEM-PLS). Hypothesis test results state that the variable social influence and price value significantly influence the dependent variable behavioral intention. While use behavior is influenced by the variable facilitating conditions and habits significantly. This is supported by the value of the path coefficient which shows that behavioral intention is positively influenced by social influence and price value with a value of 0.321 and 0.350. While the use behavior is influenced by facilitating conditions and habits of 0.261 and 0.563. Based on the results of the hypothesis testing the T Statistics values for the three moderating variables age, gender, and experience did not meet the significance standard. This means that age, gender, and length of work have no effect on the acceptance of the modul Kepegawaian SIESTA.