In the present research, micromorphological features of 10 Salvia L. nutlets (mericarp) growing in NE Iran were studied by SEM. These species were divided into three and four groups based on the shape and ornamentation of nutlets respectively. The variation in color, size and ornamentation of mericarp helped to identify species.

BackgroundThe lack of personal and social hygiene has led to the spread of infectious diseases in society (1). In addition, drug-resistant bacterial and fungal pathogenic strains have increasingly spread because of the inappropriate and unnecessary use of antibiotics and antifungal agents (2). As a result, the discovery, design, and synthesis of new antimicrobial compounds have become an inevitable necessity in the field of hygiene and healthcare (3). Dithiocarbamates are biologically active organic compounds containing the -N(C=S)S-moiety, which are usually prepared in the presence of a base from the reaction of amines or their equivalent derivatives with carbon disulfide (4). According to (5), numerous available functional groups in dithiocarbamates have given them diverse therapeutic properties (Figure 1). Thiram is a potent scabicidal drug, which is especially prescribed for the treatment of skin diseases. It is also used as a fungicide in agriculture (6). In addition, dithiocarb as a chelating agent helps to remove toxic metals from body tissues (7). Further, (8) confirmed the inhibitory effects of brassinin derivatives on cancer cell lines, especially human clones (Caco-2). Furthermore, the blocking properties of valine dithiocarbamate zinc(II) complex against breast cancer cells (MCF-7) were more pronounced compared to cisplatin (9). Moreover, the excellent inhibitory effects against two β-carbonic anhydrase enzymes belonging to pathogenic Mycobacterium tuberculosis were observed with N-mono-and N-,N-disubstituted dithiocarbamates (10). The varied biological properties of dithiocarbamates encouraged us to synthesize several derivatives of this family via the reaction of different benzhydrazines and carbon disulfide, and their antimicrobial properties were assessed against a wide range of bacterial and fungal pathogens. Materials and Methods ChemicalsAll chemicals were purchased from Merck Company (Germany). The progress of the reaction was checked by aluminum thin-layer chromatography plates (20 × 20 cm) with silica gel 60 coated with the fluorescent indicator