Objectives: To determine central macular thickness (CMT) in Diabeticretinopathy (DR) in type 2 diabetic subjects. Study Design: Cross sectional comparative study.Place & Duration: Department of Ophthalmology, Al- Ibrahim Eye Hospital & Al-Tibri MedicalCollege, Karachi from June 2014 to May 2015. Subjects & Methods: A sample of 200 diabeticswas examined. Ophthalmological examination was performed and included the best correctedvisual acuity (BCVA), anterior and posterior segment examination was performed. A +90dioptre lens was used for the anterior and posterior segment examination. Optical coherencetomography (OCT) was used with Zeiss Cirrus HD– OCT 500. Central macular thickness (CMT)was defined as an average 1 millimeter CMT. Three reading of CMT were taken and average ofthree was calculated. Data was analyzed on SPSS 23.0 ver at 95% confidence interval (P value<0.05). Results: Mean age was found 50.53± 13.75 years. Of 200 study subjects 150 (75%)were male and 50 (25%) were female (M: F ratio 3:1). Hemoglobin A1c was noted as 9.78±3.31.Central macular thickness (CMT) in HbA1c <7.0% and >7.0% was noted as 521.73±33.50 and348.47± 34.33 μm respectively (P=0.0001). Conclusion: Diabetics with retinopathy must befollowed up frequently to examine for central macular thickness to prevent visual loss. Opticalcoherence tomography is best available technique to detect the central macular thickness.

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