Zirconia have become widely studied as consequence of their outstanding mechanical properties, such as hardness, mechanical strength and fracture toughness, which allow them to cover a wide spectrum of applications as structural ceramics, including the field of biomaterials. This study was to compare the strength properties of zirconia block with and without Cold Isostatic Press (CIP). The mechanical properties of zirconia block with and without CIP were characterized. Samples of zirconia block will undergo forming process via Cold Isostatic Pressing (CIP), four levels of soaking time (no CIP, 60, 90 and 120 minutes). All of the sample with different soaking time then were sinter in the furnace. The parameter for sintering process was fixed 1300ºC at rate of 3ºC / min. All of the sample were tested for its strength properties using Vickers test. The density and shrinkage of the zirconia block was be analyzed. Scanning Electron Microscope (SEM) and X-Ray Diffraction (XRD) were used to characterize samples if zirconia blocks.