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Background: The gap in the knowledge of interns between brand names, generic name and indication of a drug can lead to unwanted clinical consequences. This study was conducted to assess the knowledge of interns at a tertiary care hospital regarding the generic name and indications of the routinely prescribed brand names of drugs.Methods: In this study, interns were required to write whether they prescribed the brand names mentioned in the questionnaire in the preceding six months, their generic name and the indication for their use. Results were expressed using descriptive statistics.Results: All brands except Zovobact SB was prescribed by more than 50% of interns in the preceding six months. The generic equivalents were correctly identified by good percentage of interns for Hicet (100%), Asthalin (95%), Cifran (90%) but the percentage of correct answers was low for other brands. For combination brands, correct generic names of all components were identified by more than 50% of interns for oflox TZ (93%), Septid D (68%) and Losar H (68%). The percentage of correct response for the indication of the brands was satisfactory for Hicet (100%), Asthalin (98%), Cifran (98%), Zerodol P (100%), Cyclopam (100%), oflox TZ (100%), Losar H (98%), Septid D (98%) but was inadequate for Taxim O (48%), Betaloc (33%), Valium (23%), Diamox (0%), Quadriderm (31%) and Zovobact SB (31%).Conclusions: This study identified lacunas in the knowledge of interns regarding generic equivalents and indications of brand names. Strategies to overcome the problem should be devised to ensure patient safety.

The present study was to see the effect of aqueous extract of seeds of Lagenaria siceraria (AELSS) on urine volume and electrolytes in swiss albino rats and to compare with standard drug Hydrochlorothiazide. Thirty male Swiss albino rats aged ten to twelve weeks of male sex weighing about 200-225 g were taken, and after acute toxicity studies two different doses were selected. The animals were divided into five different groups. The first group was kept as the control (Normal Saline) group I, second as the standard (Hydrochlorothiazide) group II and the remaining two groups as Test III and Test IV, and given different doses of the AELSS. Diuretic and Natriuretic activities were carried out by administration of normal saline along with the treatment modules. The volume of urine (in ml) and the Na + , K + and Clcontent in the urine were measured. The extract at 100 and 200 mg/kg, produced significant (P-values < 0.05) Saluretic, Natriuretic, increased potassium elimination and decreased urinary volume. Thus the study elucidates that aqueous extract of seeds of Lagenaria siceraria possess significant aquatic, Saluretic, Natriuretic activity.