The members of the writing committee assume responsibility for the overall content and integrity of this article. The full names, academic degrees, and affiliations of the members of the writing committee are listed in the Appendix.

Background Cervical cancer is the fourth most common cancer in the world, affecting mainly women residing in low- and middle-income countries. Progression from a pre-invasive phase to that of an invasive phase generally takes years and provides a window of opportunity to screen for and treat precancerous lesions. Methods This study is being conducted at four sites in north Karnataka, India. Community sensitization activities have been organized in the study areas to create awareness among stakeholders, including elected representatives, physicians, health care workers, and potential participants. Organized community based as well as hospital-based screening is being conducted using visual inspection with acetic acid (VIA). Screen positive women are referred to respective study hospitals for colposcopy and directed biopsy. Participants with confirmed high-grade cervical dysplasia (high-grade squamous intraepithelial lesions or HSIL) who fit all other eligibility criteria will be recruited to the study and will receive cryotherapy using CryoPop®, an innovative new cryotherapy device. Discussion There is a need to develop an inexpensive, simple, and effective cryotherapy device for use by frontline health care providers at locations where screening and timely treatment can be given, accelerating access to cervical cancer prevention services and minimizing loss to follow-up of women with precancerous lesions who need treatment. Trial registration Clinical Trial Registry - India CTRI/2019/01/017289 ClinicalTrials.Gov number NCT04154644. Registered on November 6, 2019.

Introduction: Excessive menstruation outside the normal parameters is one of the most common manifestations of hypothyroidism affecting the females. Thyroid disorders, such as hypothyroidism and hyperthyroidism are associated with late onset puberty, anovulatory cycles and abnormally high incidence of foetal morbidity and mortality. Aim: To study the association of bleeding pattern with thyroid dysfunction among patients with abnormal uterine bleeding. Materials and Methods: This was a prospective cross-sectional study carried out in the Department of Obstetrics and Gynaecology at Shri BM Patil Medical College, Hospital and Research Center, Vijayapura, Karnataka, India, from October 2012 to June 2014, among 140 female with a provisional diagnosis of abnormal uterine bleeding were subjected to testing for serum Triiodothyronine (T3), Thyroxine (T4), Thyroid Stimulating Hormone (TSH) and Thyroid Peroxidase (TPO) antibodies estimation in their serum. Data was analysed using Chi-square test and the p-value<0.05 was considered significant. Results: Total of 140 patients, with maximum number of patients in the study belonged to the age group 31-40 years (57,40.71%) and 46 (32.8%) patients were para 2. Among different bleeding patterns observed, most common was menorrhagia 62 (44.28%). The prevalence of subclinical hypothyroidism was 10 (7.14%), there were five hypothyroid cases (3.5%), and two hyperthyroid cases (1.4%) among 140 cases. The total thyroid disorders associated were 17 (12.14%). Conclusion: In this study association of thyroid dysfunction with AUB has been noted. With early diagnosis of thyroid disorders in AUB patients followed by appropriate treatment, the menstrual irregularities can be resolved and major surgical procedures can be avoided.

Background: 85% of women delivering vaginally experience perineal trauma, and almost two-thirds require perineal tear repair [1] . Although chromic catgut is used as standard suture, newer materials like Polyglactin 910 question the best available properties [2] . Methods: This prospective, comparative study was conducted in Shri BM Patil Medical College, Karnataka from November 2019 to November 2020. 200 women divided randomly into Catgut (group 1) vs Polyglactin (group 2). Results obtained after evaluation at 24-48 hours, 10-14 days and 6-8 weeks postnatally. Results: At 24 to 48hrs postpartum 18% had severe pain in Group 1 whereas 6% in Group 2. Similar trends observed at subsequent follow ups. 54% felt tightness/Uncomfortable in Group 1 and 83% had no such complaints in Group 2 (P<0.0001). Wound gaping in Group 1 was 14% vs 4% in Group 1 after 10 to 14 days. However none required resuturing. Residual sutures at 6 weeks postpartum Group 1 vs 2 (0% vs 13%, p value = 0.002). Conclusion:Fast-absorbing Polyglactin efficient in lessening morbidity such as significant diminution in terms of pain, discomfort, analgesia, wound dehiscence, resuturing. Hence contemplated in place of time honoured chromic catgut traditionally used for perineal repair.

No abstract