Background & Objective(s): Job burnout and satisfaction of healthcare providers are important elements of quality of provided health services. Aim of the study: This study aimed to assess the levels of burnout and job satisfaction as well as their correlates among healthcare providers in Aswan University Hospital. Methods: : A cross sectional study design was applied. Interviewing questionnaire was filled from 134 physicians and 149 nurses (total 283) working in clinical departments in Aswan University Hospital. The questionnaire included personal and job characteristics, assessment of burnout using Maslach burnout inventory (MBI), evaluation of Job satisfaction by applying short form of Minnesota satisfaction questionnaire and measurement of satisfaction with life (SWLS) and flourishing status using Diner scales. Results: Proportion of high level in burnout dimensions were as follows: emotional exhaustion was 50%, low personal accomplishment was 39% and depersonalization was 33%. The mean job satisfaction score among the studied population was 63.81±15.37 out of 100. Increasing age was a significant predictor for emotional exhaustion. Currently unmarried significantly perceived higher emotional exhaustion and depersonalization. Higher job satisfaction scores significantly predicted low perception of emotional exhaustion and depersonalization and high personal accomplishment. The significant predictors for job satisfaction were current unmarried status, working as nurse, residing outside Aswan, age increase, high personal accomplishment score and low emotional exhaustion score. Conclusion: Considerable levels of burnout were detected among healthcare providers in Aswan University Hospital. Increasing age, being originally from outside Aswan Governorate and being currently unmarried were significant correlates of burnout and job dissatisfaction. Recommendations: Modification in the work nature could be conducted for old aged healthcare providers. Social support activities such as recreational activities and moral incentives, should be promoted especially for those who are unmarried and residents from outside Aswan Governorate.