<p class="abstract"><strong>Background:</strong> Otitis media (OM) is an infectious disease that frequently affects all age brackets, including children and adults. The morbidity and complication rates of OM have been increasing in developing countries due to poor medical environments for early treatment, resulting in reductions in quality of life. Appropriate early treatment, including the use of appropriate antibiotics, is essential, requiring information on bacteriology and antibiotic sensitivity. The objective of this was to study the bacteriology of chronic suppurative otitis media (CSOM) and provide recommendations according to susceptibility pattern to commonly used antibiotics based on the experience of ENT department in S. Nijalingappa Medical College.</p><p class="abstract"><strong>Methods:</strong> Ear swabs were subjected to culture on specific culture media for bacterial growth for CSOM outpatients in S. N. Medical College, Bagalkot.  </p><p class="abstract"><strong>Results:</strong> The most effective antibiotic is amikacin followed by gentamicin and cefotaxime in both isolates namely <em>Pseudomonas</em> spp and <em>Staphylococcus aureus</em> in infected ear discharge of CSOM patients in the ENT OPD.</p><p class="abstract"><strong>Conclusions:</strong> It was observed that varieties of colonies were grown on the specific cultured medium. Appropriate antibiotics can thus be found to control infection in CSOM patients.</p>